UPDATED 7.51pm: State Highway 3 north of Te Kuiti is open again after two people died and four others were injured in a two-car crash this afternoon.

Emergency services were called to the incident on Te Kumi Road on the outskirts of Te Kuiti just after 2pm.

Firefighters cut one person out of a vehicle.

Three rescue helicopters also attended the crash.

A Waikato Westpac Rescue Helicopter spokesman said six people were involved in the crash.

Two people died and four were injured. Two of the injured, an adult and a child, were in a critical condition. Two more were in a serious condition.

All were flown to Waikato Hospital.

The names of those who dies have not yet been released.

Inspector Peter Raynes of northern police communications said the crash was car versus car, but he was unsure whether it was a head-on collision.

"We had a large presence at the scene and information is slowly coming back to us on what happened," he said.

An attendant at Z petrol station on Te Kumi Rd said the crash scene appeared to be near the Gadsby Road intersection.

Te Kuiti New World checkout supervisor Margaret Maina said just before 4pm she could hear helicopters leaving the site.

"There's been lots of police around and the road's been blocked off for almost an hour and a half."

Waikato police investigate separate fatal crash

Waikato police are also investigating the circumstances surrounding another fatal Waikato crash.

A 19-year-old Hamilton man was the sole occupant of a southbound vehicle on Scotsman Valley Road at Tauwhare when he may have lost control, the vehicle colliding with a tree.

The man died at the scene.

The vehicle crashed just before 10pm Friday.