Johnny Depp has reignited a war of words with Deputy Prime Minister Barnaby Joyce saying he looks like he was "inbred with a tomato".

The Hollywood actor took a swipe at Mr Joyce, who threatened to have Depp's dogs put down last May unless they left the country, after they violated Australia's biosecurity laws.

In an interview on Jimmy Kimmel Live, Depp made fun of the Agriculture minister's face, saying he looks like he's about to explode.

Mr Joyce in return laughed off the insults, saying he's happy he's still haunting Depp.