Last year was the worst since conflict started in Syria, UNICEF are saying.
Nearly 400 children were reported injured, and over 900 were killed.
Juliette Touma, UNICEF's Regional Chief of Communications in the Middle East, says while all children in Syria are vulnerable, those with disabilities need even more help.
She says that disabled children need much more specialised care, such as additional medicine, personal assistance and equipment like wheelchairs.
Ms Touma says the international community needs to come together and help put an end to the war. No where is safe in Syria, with violence having reached children's schools, hospitals, playgrounds and even their homes.
UNICEF is asking for $1.1 billion to help protect children, including the more than 2.5 million refugees in neighbouring countries, while the conflict continues.
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