Israeli officials have claimed Iran's Supreme Leader has been killed, following the US and Israel's major military operation on the country. 

The Iranian Red Cross says more than 200 people have been killed in strikes, including 85 people at a girls' school.

Iran has hit back in retaliation, launching missiles across the Middle East, including in Dubai, Doha, Bahrain and Kuwait - all of which either have US military bases, or are allied to the US.

Middle East correspondent for the Economist, Greg Carlstrom, says it's unclear how a regime change will change the Iranian Government dramatically.

"The Iranian opposition, the political opposition is deeply divided, it's disorganised, there isn't someone who is an obvious leader, an obvious candidate to try and assume control of the country."

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• Watch: Winston Peters holds press conference as strikes continue in Middle East