Two people are dead and eight injured after a plane crashed in San Diego overnight.

The small business jet crashed into the Murphy Canyon neighbourhood, spilling jet fuel across the road and engulfing multiple homes in flames.

Police evacuated around 100 residents.

US Correspondent Richard Arnold told Mike Hosking authorities are doing more searches, to make sure everyone's out.

He says it's believed those killed were on board, but among those injured were people on the ground.

LISTEN ABOVE