Multiple people have been handcuffed in central Auckland after a major police chase through the CBD.

Police blocked a section of Karangahape Road by the Howe St intersection at 4.30pm after at least 15 police cars were seen chasing a white vehicle.

A man with blood on his face was seen being handcuffed and placed into the back of a police car.

Others have been seen being hauled away by police.

Police have been approached for comment.

Police take a man into custody after a police chase across the city, ending in a crash on K Road. Photo / Dean Purcell

Hato Hone St John spokesperson said one ambulance, one rapid response unit, and one operations manager attended a motor vehicle incident on Karangahape Road / Hereford Street.

They said one patient in moderate condition was transported to hospital.

Three additional patients, all in minor condition, were assessed at the scene.

Earlier, a witness told the Herald cars were spotted with lights and sirens speeding north, past Sylvia Park, just before 4pm.

The Herald understands the cars were headed towards downtown Auckland.

A reporter on the scene in central Auckland said a chopper was hovering above the Victoria Park area.

A witness said there was a figure “protruding” out of a vehicle.

Police were also seen around the Auckland University of Technology and outside a car dealership on Karangahape Rd.

A Herald photographer said it appeared a police officer was laying spikes at the entrance to the top of Hobson St at the entrances to the Southern and Northwestern Motorways.