A busy Ōamaru intersection is closed after a two-vehicle crash involving a motorcycle.

Emergency services responded to the crash at the intersection of Thames St and Ouse St at 12.52pm.

Police said two people were reported to have serious and moderate injuries and were being treated by ambulance staff.

The road remains closed with diversions and traffic management in place.

Motorists are advised to take Trent Street if they are travelling northbound.

Hato Hone St John has been approached for comment.