A mass brawl on a popular Auckland nightlife strip has ended with multiple arrests and a person in hospital with serious injuries.

Police were called to Auckland’s Karangahape Rd just after 3.30am following multiple reports of a mass disorder and large fight on the street.

Officers attended to disperse the crowd of around 50 people.

Hato Hone St John sent an ambulance to the scene, where one person had been seriously injured and was taken to hospital for treatment.

Police said four people were arrested in connection to the fight.

The Karangahape Rd and Cobden St intersection, by the base of the Lighthouse Apartments, has been taped off as police investigate.

Police scene examination on K Road after a large fight took place in the early hours of this morning. Photo / Dean Purcell

A forensic examination is taking place. Photo / Dean Purcell

Residents reported hearing yelling and screaming on the street for approximately two hours following the incident, as armed police searched the area with dogs.

A large nitrous oxide canister box can be seen on the ground outside the Lighthouse Apartments.

Forensic officers and detectives are still visible in the area this morning.

The Karangahape Rd and Cobden St intersection, by the base of the Lighthouse Apartments, has been taped off. Photo / Dean Purcell