A successful drug bust's allowed Marlborough police to seize hundreds of thousands of dollars worth of assets.

In a large crackdown, police discovered 25 kilograms of cannabis on board a yacht in the Marlborough Sounds and have been authorised to seize three boats, two properties and a vehicle.

Detective Senior Sergeant Brent Murray says the investigation's continuing.

"Our role is to disrupt and dismantle the ability to earn significant profits from the sale of drugs and assist in preventing harm in the community as a result of those drugs no longer being available."

One man will appear in court this week on sale and cultivation charges, two other men have also been charged.