Two people have died and multiple are with injuries after a crash in Hawke's Bay.

The incident happened on Sandy Road, Meeanee, around 4.35pm this afternoon.

A third passenger in the same vehicle of the two that died has serious injuries.

There were two occupants in the second vehicle, a man with minor injuries and a woman, who was uninjured.

The Serious Crash Unit are in attendance and diversions remain in place.

The road is expected to be closed for at least another hour.