Two people are dead and eleven others injured after a spate of smashes on Waikato roads over the weekend.

The first fatality happened on Friday night, when a man was killed after two cars collided in Matamata.

Four people in the other vehicle were injured, with two flown to Waikato Hospital.

On Saturday afternoon, a 55 year old lost control of his motorcycle and crashed into a bank in the Coromandel.

He later died in hospital.

Meanwhile, an elderly couple were airlifted to hospital and two other people left injured after a collision between two vehicles near Otorohanga yesterday morning.

And three people were flown to hospital in the afternoon, following another two-car crash on the lower Kaimai Ranges.